Biology – Quantitative Biology – Biomolecules
Scientific paper
2012-04-05
Biology
Quantitative Biology
Biomolecules
4 pages, 6 figures, submitted, 2 typo's corrected, one reference added
Scientific paper
We use the worm-like chain model to study supercoiling of DNA under tension and torque. The model reproduces experimental data for a much broader range of forces, salt concentrations and contour lengths than previous approaches. Our theory shows, for the first time, how the behavior of the system is controlled by a multi-plectoneme phase in a wide range of parameters. This phase does not only affect turn-extension curves but also leads to a non-constant torque in the plectonemic phase. Shortcomings from previous models and inconsistencies between experimental data are resolved in our theory without the need of adjustable parameters.
Emanuel Marc
Lanzani Giovanni
Schiessel Helmut
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