Morphogen Profiles Can Be Optimised to Buffer Against Noise

Details Morphogen Profiles Can Be Optimised to Buffer Against Noise Morphogen Profiles Can Be Optimised to Buffer Against Noise

2009-04-10

arxiv.org/abs/0904.1637v1

Physical Review E: 80, 041902 (October 2009)

Biology

Quantitative Biology

Molecular Networks

5 pages, 3 figures

Scientific paper

10.1103/PhysRevE.80.041902

Morphogen profiles play a vital role in biology by specifying position in embryonic development. However, the factors that influence the shape of a morphogen profile remain poorly understood. Since morphogens should provide precise positional information, one significant factor is the robustness of the profile to noise. We compare three classes of morphogen profiles (linear, exponential, algebraic) to see which is most precise when subject to both external embryo-to-embryo fluctuations and internal fluctuations due to intrinsically random processes such as diffusion. We find that both the kinetic parameters and the overall gradient shape (e.g. exponential versus algebraic) can be optimised to generate maximally precise positional information.

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