Molecular Recognition as an Information Channel: The Role of Conformational Changes

Details Molecular Recognition as an Information Channel: The Role of Conformational Changes Molecular Recognition as an Information Channel: The Role of Conformational Changes

2010-07-26

arxiv.org/abs/1007.4467v1

Workshop on Biological and Bio-Inspired Information Theory, 43rd Annual Conference on Information Sciences and Systems, March

Biology

Quantitative Biology

Biomolecules

Keywords--Molecular information channels, molecular recognition, conformational proofreading. http://www.weizmann.ac.il/comp

Scientific paper

10.1109/CISS.2009.5054833

Molecular recognition, which is essential in processing information in biological systems, takes place in a crowded noisy biochemical environment and requires the recognition of a specific target within a background of various similar competing molecules. We consider molecular recognition as a transmission of information via a noisy channel and use this analogy to gain insights on the optimal, or fittest, molecular recognizer. We focus on the optimal structural properties of the molecules such as flexibility and conformation. We show that conformational changes upon binding, which often occur during molecular recognition, may optimize the detection performance of the recognizer. We thus suggest a generic design principle termed 'conformational proofreading' in which deformation enhances detection. We evaluate the optimal flexibility of the molecular recognizer, which is analogous to the stochasticity in a decision unit. In some scenarios, a flexible recognizer, i.e., a stochastic decision unit, performs better than a rigid, deterministic one. As a biological example, we discuss conformational changes during homologous recombination, the process of genetic exchange between two DNA strands.

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