Modular organization as a basis for the functional integration/segregation in large-scale brain networks

Details Modular organization as a basis for the functional integration/segregation in large-scale brain networks Modular organization as a basis for the functional integration/segregation in large-scale brain networks

2009-01-12

arxiv.org/abs/0901.1605v2

Physics

Data Analysis, Statistics and Probability

8 pages, 4 figures

Scientific paper

Modular structure is ubiquitous among real-world networks from related proteins to social groups. Here we analyze the modular organization of brain networks at a large-scale (voxel level) extracted from functional magnetic resonance imaging (fMRI) signals. By using a random walk-based method, we unveil the modularity of brain-webs, and show that modules with a spatial distribution that matches anatomical structures with functional significance. The functional role of each node in the network is studied by analyzing its patterns of inter- and intra-modular connections. Results suggest that the modular architecture constitutes the structural basis for the coexistence of functional integration of distant and specialized brain areas during normal brain activities at rest.

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