Modeling the effects of HIV-1 virions and proteins on Fas-induced apoptosis of infected cells

Details Modeling the effects of HIV-1 virions and proteins on Fas-induced apoptosis of infected cells Modeling the effects of HIV-1 virions and proteins on Fas-induced apoptosis of infected cells

2007-05-14

arxiv.org/abs/0705.2032v1

Biology

Quantitative Biology

Molecular Networks

preliminary version

Scientific paper

We report a first in modeling and simulation of the effects of the HIV proteins on the (caspase dependent) apoptotic pathway in infected cells. This work is novel and is an extension on the recent reports and clarifications on the FAS apoptotic pathway from the literature. We have gathered most of the reaction rates and initial conditions from the literature, the rest of the constants have been computed by fitting our model to the experimental results reported. Using the model obtained we have then run the simulations for the infected memory T cells, called also latent T cells, which, at the moment, represent the major obstacle to finding a cure for HIV. We can now report that the infected latent T cells have an estimated lifetime of about 42 hours from the moment they are re-activated. As far as we know this is the first result of this type obtained for the infected memory T cells.

Affiliated with

Also associated with

No associations

Rating

Modeling the effects of HIV-1 virions and proteins on Fas-induced apoptosis of infected cells does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Modeling the effects of HIV-1 virions and proteins on Fas-induced apoptosis of infected cells, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modeling the effects of HIV-1 virions and proteins on Fas-induced apoptosis of infected cells will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-622541