Modeling the Effects of Drug Binding on the Dynamic Instability of Microtubules

Details Modeling the Effects of Drug Binding on the Dynamic Instability of Microtubules Modeling the Effects of Drug Binding on the Dynamic Instability of Microtubules

2010-10-12

arxiv.org/abs/1010.4288v2

Physics

Biological Physics

17 pages, 11 figures, to appear in Phys. Biol

Scientific paper

We propose a stochastic model that accounts for the growth, catastrophe and rescue processes of steady state microtubules assembled from MAP-free tubulin. Both experimentally and theoretically we study the perturbation of microtubule dynamic instability by S-methyl-D-DM1, a synthetic derivative of the microtubule-targeted agent maytansine and a potential anticancer agent. We find that to be an effective suppressor of microtubule dynamics a drug must primarily suppress the loss of GDP tubulin from the microtubule tip.

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