Modeling of negative autoregulated genetic networks in single cells

Details Modeling of negative autoregulated genetic networks in single cells Modeling of negative autoregulated genetic networks in single cells

2005-04-26

arxiv.org/abs/q-bio/0504030v1

Gene, Vol. 347, Issue 2, 14 March 2005, Pages 265-271

Biology

Quantitative Biology

Molecular Networks

15 pages, 4 figures. Published in Gene

Scientific paper

10.1016/j.gene.2004.12.016

We discuss recent developments in the modeling of negative autoregulated genetic networks. In particular, we consider the temporal evolution of the population of mRNA and proteins in simple networks using rate equations. In the limit of low copy numbers, fluctuation effects become significant and more adequate modeling is then achieved using the master equation formalism. The analogy between regulatory gene networks and chemical reaction networks on dust grains in the interstellar medium is discussed. The analysis and simulation of complex reaction networks are also considered.

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