Model evaluation for glycolytic oscillations in yeast biotransformations of xenobiotics

Details Model evaluation for glycolytic oscillations in yeast biotransformations of xenobiotics Model evaluation for glycolytic oscillations in yeast biotransformations of xenobiotics

2004-04-26

arxiv.org/abs/q-bio/0404036v1

Biophysical Chemistry 109, 413-426 (2004)

Biology

Quantitative Biology

Molecular Networks

Scientific paper

10.1016/j.bpc.2003.12.004

Anaerobic glycolysis in yeast perturbed by the reduction of xenobiotic ketones is studied numerically in two models which possess the same topology but different levels of complexity. By comparing both models' predictions for concentrations and fluxes as well as steady or oscillatory temporal behavior we answer the question what phenomena require what kind of minimum model abstraction. While mean concentrations and fluxes are predicted in agreement by both models we observe different domains of oscillatory behavior in parameter space. Generic properties of the glycolytic response to ketones are discussed.

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