Microtubule Dynamics and Oscillating State for Mitotic Spindle

Details Microtubule Dynamics and Oscillating State for Mitotic Spindle Microtubule Dynamics and Oscillating State for Mitotic Spindle

2010-05-18

arxiv.org/abs/1005.3301v1

Physics

Biological Physics

Submitted to Phys. Rev. E

Scientific paper

We present a physical mechanism that can cause the mitotic spindle to oscillate. The driving force for this mechanism emerges from the polymerization of astral microtubules interacting with the cell cortex. We show that Brownian ratchet model for growing microtubules reaching the cell cortex, mediate an effective mass to the spindle body and therefore force it to oscillate. We compare the predictions of this mechanism with the previous mechanisms which were based on the effects of motor proteins. Finally we combine the effects of microtubules polymerization and motor proteins, and present the detailed phase diagram for possible oscillating states.

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