Microsatellite instability in human mammary epithelial cells transformed by heavy ions

Details Microsatellite instability in human mammary epithelial cells transformed by heavy ions Microsatellite instability in human mammary epithelial cells transformed by heavy ions

Nov 1998

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1998adspr..22.1709y&link_type=abstract

Advances in Space Research, Volume 22, Issue 12, p. 1709-1717.

Physics

Scientific paper

We analyzed DNA and proteins obtained from normal and transformed human mammary epithelial cells for studying the neoplastic transformation by high-LET irradiation in vitro. We also examined microsatellite instability in human mammary cells transformed to various stages of carcinogenesis, such as normal, growth variant and tumorigenic, using microsatellite marker D5S177 on the chromosome 5 and CY17 on the Chromosome 10. Microsatellite instabilities were detected in the tumorigenic stage. These results suggest that microsatellite instability may play a role in the progression of tumorigenecity. The cause of the genomic instability has been suggested as abnormalities of DNA-repair systems which may be due to one of the three reasons: 1) alterations of cell cycle regulating genes. 2) mutations in any of the DNA mismatch repair genes, 3) mutation in any of the DNA strand breaks repair genes. No abnormality of these genes and encoded proteins, however was found in the present studies. These studies thus suggest that the microsatellite instability is induced by an alternative mechanism.

Affiliated with

Also associated with

No associations

Rating

Microsatellite instability in human mammary epithelial cells transformed by heavy ions does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Microsatellite instability in human mammary epithelial cells transformed by heavy ions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Microsatellite instability in human mammary epithelial cells transformed by heavy ions will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-1074111