Metabolic robustness and network modularity: A model study

Details Metabolic robustness and network modularity: A model study Metabolic robustness and network modularity: A model study

2010-12-20

arxiv.org/abs/1012.4256v1

Biology

Quantitative Biology

Molecular Networks

Scientific paper

[Background] Several studies have mentioned network modularity -- that a network can easily be decomposed into subgraphs that are densely connected within and weakly connected between each other -- as a factor affecting metabolic robustness. In this paper we measure the relation between network modularity and several aspects of robustness directly in a model system of metabolism. [Methodology/Principal Findings] By using a model for generating chemical reaction systems where one can tune the network modularity, we find that robustness increases with modularity for changes in the concentrations of metabolites, whereas it decreases with changes in the expression of enzymes. The same modularity scaling is true for the speed of relaxation after the perturbations. [Conclusions/Significance] Modularity is not a general principle for making metabolism either more or less robust; this question needs to be addressed specifically for different types of perturbations of the system.

Affiliated with

Also associated with

No associations

Rating

Metabolic robustness and network modularity: A model study does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Metabolic robustness and network modularity: A model study, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Metabolic robustness and network modularity: A model study will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-452953