Master equation approach to the assembly of viral capsids

Details Master equation approach to the assembly of viral capsids Master equation approach to the assembly of viral capsids

2005-08-22

arxiv.org/abs/q-bio/0508030v1

Biology

Quantitative Biology

Biomolecules

Scientific paper

The distribution of inequivalent geometries occurring during self-assembly of the major capsid protein in thermodynamic equilibrium is determined based on a master equation approach. These results are implemented to characterize the assembly of SV40 virus and to obtain information on the putative pathways controlling the progressive build-up of the SV40 capsid. The experimental testability of the predictions is assessed and an analysis of the geometries of the assembly intermediates on the dominant pathways is used to identify targets for antiviral drug design.

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