Mapping of Heavy Chain Genes for Mouse Immunoglobulins M and D

Details Mapping of Heavy Chain Genes for Mouse Immunoglobulins M and D Mapping of Heavy Chain Genes for Mouse Immunoglobulins M and D

Sep 1980

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1980sci...209.1348l&link_type=abstract

Science, Volume 209, Issue 4463, pp. 1348-1353

Physics

24

Scientific paper

A single DNA fragment containing both μ and δ immunoglobulin heavy chain genes has been cloned from normal BALB/c mouse liver DNA with a new λ phage vector Charon 28. The physical distance between the membrane terminal exon of μ and the first domain of δ is 2466 base pairs, with δ on the 3' side of μ . A single transcript could contain a variable region and both μ and δ constant regions. The dual expression of immunoglobulins M and D on spleen B cells may be due to alternate splicing of this transcript.

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