Manipulating single enzymes by an external harmonic force

Details Manipulating single enzymes by an external harmonic force Manipulating single enzymes by an external harmonic force

2006-11-03

arxiv.org/abs/q-bio/0611011v2

Phys. Rev. Lett. 98, 168302 (2007)

Biology

Quantitative Biology

Biomolecules

4 pages, 6 figures, minor changes, to appear in Phys. Rev. Lett

Scientific paper

10.1103/PhysRevLett.98.168302

We study a Michaelis-Menten reaction for a single two-state enzyme molecule, whose transition rates between the two conformations are modulated by an harmonically oscillating external force. In particular, we obtain a range of optimal driving frequencies for changing the conformation of the enzyme thereby controlling the enzymatic activity (i.e. product formation). This analysis demonstrates that it is, in principle, possible to obtain information about particular rates within the kinetic scheme.

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