Manipulating Biopolymer Dynamics by Anisotropic Nanoconfinement

Details Manipulating Biopolymer Dynamics by Anisotropic Nanoconfinement Manipulating Biopolymer Dynamics by Anisotropic Nanoconfinement

2007-10-08

arxiv.org/abs/0710.1657v2

Physics

Biological Physics

to appear in Nano Letters

Scientific paper

How the geometry of nano-sized confinement affects dynamics of biomaterials is interesting yet poorly understood. An elucidation of structural details upon nano-sized confinement may benefit manufacturing pharmaceuticals in biomaterial sciences and medicine. The behavior of biopolymers in nano-sized confinement is investigated using coarse-grained models and molecular simulations. Particularly, we address the effects of shapes of a confinement on protein folding dynamics by measuring folding rates and dissecting structural properties of the transition states in nano-sized spheres and ellipsoids. We find that when the form of a confinement resembles the geometrical properties of the transition states, the rates of folding kinetics are most enhanced. This knowledge of shape selectivity in identifying optimal conditions for reactions will have a broad impact in nanotechnology and pharmaceutical sciences.

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