Looking for packing units of the protein structure

Details Looking for packing units of the protein structure Looking for packing units of the protein structure

2011-09-13

arxiv.org/abs/1109.2683v1

Biology

Quantitative Biology

Biomolecules

10 pages, 5 tables

Scientific paper

Lattice-model simulations and experiments of some small proteins suggest that folding is essentially controlled by a few conserved contacts. Residues of these conserved contacts form the minimum set of native contacts needed to ensure foldability. Keeping such conserved specific contacts in mind, we examine contacts made by two secondary structure elements of different helices or sheets and look for possible 'packing units' of the protein structure. Two short backbone fragments of width five centred at the C? atoms in contact is called an H-form, which serves as a candidate for the packing units. The structural alignment of protein family members or even across families indicates that there are conservative H-forms which are similar both in their sequences and local geometry, and consistent with the structural alignment. Carrying strong sequence signals, such packing units would provide 3D constraints as a complement of the potential functions for the structure prediction.

Affiliated with

Also associated with

No associations

Rating

Looking for packing units of the protein structure does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Looking for packing units of the protein structure, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Looking for packing units of the protein structure will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-333100