Biology – Quantitative Biology – Biomolecules
Scientific paper
2003-11-24
Biology
Quantitative Biology
Biomolecules
4 pages, 1 figure
Scientific paper
How DNA repair enzymes find the relatively rare sites of damage is not known in great detail. Recent experiments and molecular data suggest that the individual repair enzymes do not work independently of each other, but rather interact with each other through currents exchanged along DNA. A damaged site in DNA hinders this exchange and this makes it possible to quickly free up resources from error free stretches of DNA. Here the size of the speedup gained from this current exchange mechanism is calculated and the characteristic length and time scales are identified. In particular for Escherichia coli we estimate the speedup to be 50000/N, where N is the number of repair enzymes participating in the current exchange mechanism. Even though N is not exactly known a speedup of order 10 is not entirely unreasonable. Furthermore upon over expression of repair enzymes the detection time only varies as one over the squareroot of N and not as 1/N. This behavior is of interest in assessing the impact of stress full and radioactive environments on individual cell mutation rates.
No associations
LandOfFree
Localization of DNA damage by current exchanging repair enzymes: effects of cooperativity on detection time does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with Localization of DNA damage by current exchanging repair enzymes: effects of cooperativity on detection time, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Localization of DNA damage by current exchanging repair enzymes: effects of cooperativity on detection time will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-20302