Physics – Biological Physics
Scientific paper
2008-09-11
Reports on Progress in Physics 62 (1999) 921-968
Physics
Biological Physics
Scientific paper
10.1088/0034-4885/62/6/202
The formation and dissociation of specific noncovalent interactions between a variety of macromolecules play a crucial role in the function of biological systems. During the last few years, three main lines of research led to a dramatic improvement of our understanding of these important phenomena. First, combination of genetic engineering and X ray cristallography made available a simultaneous knowledg of the precise structure and affinity of series or related ligand-receptor systems differing by a few well-defined atoms. Second, improvement of computer power and simulation techniques allowed extended exploration of the interaction of realistic macromolecules. Third, simultaneous development of a variety of techniques based on atomic force microscopy, hydrodynamic flow, biomembrane probes, optical tweezers, magnetic fields or flexible transducers yielded direct experimental information of the behavior of single ligand receptor bonds. At the same time, investigation of well defined cellular models raised the interest of biologists to the kinetic and mechanical properties of cell membrane receptors. The aim of this review is to give a description of these advances that benefitted from a largely multidisciplinar approach.
No associations
LandOfFree
Ligand-Receptor Interactions does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with Ligand-Receptor Interactions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ligand-Receptor Interactions will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-473552