Less is more: removing membrane attachments stiffens the RBC cytoskeleton

Details Less is more: removing membrane attachments stiffens the RBC cytoskeleton Less is more: removing membrane attachments stiffens the RBC cytoskeleton

Nov 2007

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2007njph....9..429g&link_type=abstract

New Journal of Physics, Volume 9, Issue 11, pp. 429 (2007).

Physics

1

Scientific paper

The polymerized network of the cytoskeleton of the red-blood cell (RBC) contains different protein components that maintain its overall integrity and attachment to the lipid bilayer. One of these key components is the band 3 ankyrin complex that attaches the spectrin filaments to the fluid bilayer. Defects in this particular component result in the shape transformation called spherocytosis, through the shedding of membrane nano-vesicles. We show here that this transition and membrane shedding can be explained through the increased stiffness of the network when the band 3 ankyrin complexes are removed. ATP-induced transient dissociations lead to network softening, which offsets the stiffening to some extent, and causes increased fragility of these mutant cells, as is observed.

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