Leader neurons in population bursts of 2D living neural networks

Details Leader neurons in population bursts of 2D living neural networks Leader neurons in population bursts of 2D living neural networks

Jan 2008

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2008njph...10a5011e&link_type=abstract

New Journal of Physics, Volume 10, Issue 1, pp. 015011 (2008).

Physics

4

Scientific paper

Eytan and Marom (2006 J. Neurosci. 26 8465 76) recently showed that the spontaneous bursting activity of rat neuron cultures includes 'first-to-fire' cells that consistently fire earlier than others. Here, we analyze the behavior of these neurons in long-term recordings of spontaneous activity of rat hippocampal and rat cortical neuron cultures from three different laboratories. We identify precursor events that may either subside ('aborted bursts') or can lead to a full-blown burst ('pre-bursts'). We find that the activation in the pre-burst typically has a first neuron ('leader'), followed by a localized response in its neighborhood. Locality is diminished in the bursts themselves. The long-term dynamics of the leaders is relatively robust, evolving with a half-life of 23 34 h. Stimulation of the culture alters the leader distribution, but the distribution stabilizes within about 1 h. We show that the leaders carry information about the identity of the burst, as measured by the signature of the number of spikes per neuron in a burst. The number of spikes from leaders in the first few spikes of a precursor event is furthermore shown to be predictive with regard to the transition into a burst (pre-burst versus aborted burst). We conclude that the leaders play a role in the development of the bursts and conjecture that they are part of an underlying sub-network that is excited first and then acts as a nucleation center for the burst.

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