Kinetic proofreading of gene activation by chromatin remodeling

Biology – Quantitative Biology – Molecular Networks

Scientific paper

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8 pages, 2 Figures; application added

Scientific paper

10.2976/1.2909080

Gene activation in eukaryotes involves the concerted action of histone tail modifiers, chromatin remodellers and transcription factors, whose precise coordination is currently unknown. We demonstrate that the experimentally observed interactions of the molecules are in accord with a kinetic proofreading scheme. Our finding could provide a basis for the development of quantitative models for gene regulation in eukaryotes based on the combinatorical interactions of chromatin modifiers.

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