Biology – Quantitative Biology – Molecular Networks
Scientific paper
2008-01-09
Biology
Quantitative Biology
Molecular Networks
8 pages, 2 Figures; application added
Scientific paper
10.2976/1.2909080
Gene activation in eukaryotes involves the concerted action of histone tail modifiers, chromatin remodellers and transcription factors, whose precise coordination is currently unknown. We demonstrate that the experimentally observed interactions of the molecules are in accord with a kinetic proofreading scheme. Our finding could provide a basis for the development of quantitative models for gene regulation in eukaryotes based on the combinatorical interactions of chromatin modifiers.
Blossey Ralf
Schiessel Helmut
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