Kinetic model of DNA replication in eukaryotic organisms

Details Kinetic model of DNA replication in eukaryotic organisms Kinetic model of DNA replication in eukaryotic organisms

2001-01-25

arxiv.org/abs/physics/0101087v2

J.Mol.Biol., 320, 741-750 (2002)

Physics

Biological Physics

10 pages, 6 figures: see also cond-mat/0306546 & physics/0306156

Scientific paper

We formulate a kinetic model of DNA replication that quantitatively describes recent results on DNA replication in the in vitro system of Xenopus laevis prior to the mid-blastula transition. The model describes well a large amount of different data within a simple theoretical framework. This allows one, for the first time, to determine the parameters governing the DNA replication program in a eukaryote on a genome-wide basis. In particular, we have determined the frequency of origin activation in time and space during the cell cycle. Although we focus on a specific stage of development, this model can easily be adapted to describe replication in many other organisms, including budding yeast.

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