ITM Probe: analyzing information flow in protein networks

Details ITM Probe: analyzing information flow in protein networks ITM Probe: analyzing information flow in protein networks

2009-04-17

arxiv.org/abs/0904.2770v1

Bioinformatics 2009 25(18):2447-2449

Biology

Quantitative Biology

Molecular Networks

5 pages, 1 figure

Scientific paper

10.1093/bioinformatics/btp398

Summary: Founded upon diffusion with damping, ITM Probe is an application for modeling information flow in protein interaction networks without prior restriction to the sub-network of interest. Given a context consisting of desired origins and destinations of information, ITM Probe returns the set of most relevant proteins with weights and a graphical representation of the corresponding sub-network. With a click, the user may send the resulting protein list for enrichment analysis to facilitate hypothesis formation or confirmation. Availability: ITM Probe web service and documentation can be found at www.ncbi.nlm.nih.gov/CBBresearch/qmbp/mn/itm_probe

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