Biology – Quantitative Biology – Biomolecules
Scientific paper
2009-06-13
Physical Review E 80, 031902 (2009)
Biology
Quantitative Biology
Biomolecules
Typos corrected
Scientific paper
10.1103/PhysRevE.80.031902
We carry out a theoretical study on the isotropic-nematic phase transition and phase separation in amyloid fibril solutions. Borrowing the thermodynamic model employed in the study of cylindrical micelles, we investigate the variations in the fibril length distribution and phase behavior with respect to changes in the protein concentration, fibril's rigidity, and binding energy. We then relate our theoretical findings to the nematic ordering observed in Hen Lysozyme fibril solution.
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