Isolating intrinsic noise sources in a stochastic genetic switch

Physics – Biological Physics

Scientific paper

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

25 pages, 5 figures

Scientific paper

The stochastic mutual repressor model is analysed using perturbation methods. This simple model of a gene circuit consists of two genes and three promotor states. Either of the two protein products can dimerize, forming a repressor molecule that binds to the promotor of the other gene. When the repressor is bound to a promotor, the corresponding gene is not transcribed and no protein is produced. Either one of the promotors can be repressed at any given time or both can be unrepressed, leaving three possible promotor states. This model is analysed in its bistable regime in which the deterministic limit exhibits two stable fixed points and an unstable saddle, and the case of small noise is considered. On small time scales, the stochastic process fluctuates near one of the stable fixed points, and on large time scales, a metastable transition can occur, where fluctuations drive the system past the unstable saddle to the other stable fixed point. To explore how different intrinsic noise sources affect these transitions, fluctuations in protein production and degradation are eliminated, leaving fluctuations in the promotor state as the only source of noise in the system. Perturbation methods are then used to compute the stability landscape and the distribution of transition times, or first exit time density. To understand how protein noise affects the system, small magnitude fluctuations are added back into the process, and the stability landscape is compared to that of the process without protein noise. It is found that significant differences in the random process emerge in the presence of protein noise.

No associations

LandOfFree

Say what you really think

Search LandOfFree.com for scientists and scientific papers. Rate them and share your experience with other people.

Rating

Isolating intrinsic noise sources in a stochastic genetic switch does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Isolating intrinsic noise sources in a stochastic genetic switch, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Isolating intrinsic noise sources in a stochastic genetic switch will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFWR-SCP-O-704701

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.