Intra-cellular transport of single-headed molecular motors KIF1A

Details Intra-cellular transport of single-headed molecular motors KIF1A Intra-cellular transport of single-headed molecular motors KIF1A

2005-06-02

arxiv.org/abs/physics/0506014v2

Physical Review Letters, 95 (2005) 118101

Physics

Biological Physics

4 pages, REVTEX, 5 EPS figures; Accepted for Publication in Phys. Rev. Lett

Scientific paper

10.1103/PhysRevLett.95.118101

Motivated by experiments on single-headed kinesin KIF1A, we develop a model of intra-cellular transport by interacting molecular motors. It captures explicitly not only the effects of ATP hydrolysis, but also the ratchet mechanism which drives individual motors. Our model accounts for the experimentally observed single molecule properties in the low density limit and also predicts a phase diagram that shows the influence of hydrolysis and Langmuir kinetics on the collective spatio-temporal organization of the motors. Finally, we provide experimental evidence for the existence of domain walls in our {\it in-vitro} experiment with fluorescently labeled KIF1A.

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