Biology – Quantitative Biology – Molecular Networks
Scientific paper
2009-08-11
J Biol Chem 285,(2), 2010
Biology
Quantitative Biology
Molecular Networks
Whole Manuscript 33 pages inclduing Main text, 7 Figures and Supporting Information
Scientific paper
10.1074/jbc.M109.055863
We mathematically modeled the receptor-activated MAP kinase signaling by incorporating the regulation through cellular phosphatases. Activation induced the alignment of a phosphatase cascade in parallel with the MAP kinase pathway. A novel regulatory motif was thus generated, providing for the combinatorial control of each MAPK intermediate. This ensured a non-linear mode of signal transmission with the output being shaped by the balance between the strength of input signal, and the activity gradient along the phosphatase axis. Shifts in this balance yielded modulations in topology of the motif, thereby expanding the repertoire of output responses. Thus we identify an added dimension to signal processing, wherein the output response to an external stimulus is additionally filtered through indicators that define the phenotypic status of the cell.
Chaudhri Virendra K.
Dua Raina
Kumar Dhiraj
Misra Manjari
Rao Kanury V. S.
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