Instrument for noninvasive photonic assessments of biological materials

Details Instrument for noninvasive photonic assessments of biological materials Instrument for noninvasive photonic assessments of biological materials

Oct 2004

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2004spie.5578..278f&link_type=abstract

Photonics North 2004: Optical Components and Devices. Edited by Armitage, John C.; Fafard, Simon; Lessard, Roger A.; Lampropoul

Physics

Optics

Scientific paper

We have developed a new instrument for the non-invasive assessment of biological materials. The instrument assesses sample condition, by measuring the interaction of the biological material with optical radiation. The new instrument features efficient light collection optics, improved light delivery and increased measurement flexibility over previous designs. The optical properties measured are: refracted (transmitted), forward scattered, non-specularly reflected and specularly reflected light. Measurements were made for white light, as well as in several spectral regions over the visible spectrum. The instrument repeatability using non-biological controls was between 0.08% and 0.34% of maximum signal for each of the four optical properties for signals ranging from maximum to 0.1% maximum, for each of the wavelengths ranges. This repeatability is better than the variability of biological samples within a test group, which is 5% of maximum signal and ensures that the instrument will be able to accurately report the optical property of biological systems. The instrument is also capable of detecting changes of between 0.0063% and 0.0057% of maximum signal for each of the four optical properties and in each wavelength range. Using artificial, human, and porcine corneas, measurements were made to assess and quantify the system"s ability to characterize changes in the above optical properties in a biological system under stress. For both transmitted and reflected non-specular light, there was an equivalent correlation measured between artificial and human corneas, when exposed to an external insult. The instrument also proved effective in tracking time-dependant responses of biological tissues subjected to various insults. This new instrument is a reliable tool for measuring static and dynamic optical properties of various biological tissues. The ability to measure small relative changes in optical properties of tissues makes it an invaluable diagnostic tool.

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