Inhibition of protein crystallization by evolutionary negative design

Details Inhibition of protein crystallization by evolutionary negative design Inhibition of protein crystallization by evolutionary negative design

2004-02-16

arxiv.org/abs/q-bio/0402033v1

Physical Biology 1, P9-P13 (2004)

Biology

Quantitative Biology

Biomolecules

5 pages

Scientific paper

10.1088/1478-3967/1/1/P02

In this perspective we address the question: why are proteins seemingly so hard to crystallize? We suggest that this is because of evolutionary negative design, i.e. proteins have evolved not to crystallize, because crystallization, as with any type of protein aggregation, compromises the viability of the cell. There is much evidence in the literature that supports this hypothesis, including the effect of mutations on the crystallizability of a protein, the correlations found in the properties of crystal contacts in bioinformatics databases, and the positive use of protein crystallization by bacteria and viruses.

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