Information theory in molecular biology

Details Information theory in molecular biology Information theory in molecular biology

2004-05-05

arxiv.org/abs/q-bio/0405004v1

Physics of Life Reviews 1 (2004) 3-22

Biology

Quantitative Biology

Biomolecules

29 pages, 7 figs

Scientific paper

10.1016/j.plrev.2004.01.002

This article introduces the physics of information in the context of molecular biology and genomics. Entropy and information, the two central concepts of Shannon's theory of information and communication, are often confused with each other but play transparent roles when applied to statistical ensembles (i.e., identically prepared sets) of symbolic sequences. Such an approach can distinguish between entropy and information in genes, predict the secondary structure of ribozymes, and detect the covariation between residues in folded proteins. We also review applications to molecular sequence and structure analysis, and introduce new tools in the characterization of resistance mutations, and in drug design.

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