Information flow and optimization in transcriptional control

Details Information flow and optimization in transcriptional control Information flow and optimization in transcriptional control

2007-05-02

arxiv.org/abs/0705.0313v1

Biology

Quantitative Biology

Molecular Networks

5 pages, 4 figures

Scientific paper

10.1073/pnas.0806077105

In the simplest view of transcriptional regulation, the expression of a gene is turned on or off by changes in the concentration of a transcription factor (TF). We use recent data on noise levels in gene expression to show that it should be possible to transmit much more than just one regulatory bit. Realizing this optimal information capacity would require that the dynamic range of TF concentrations used by the cell, the input/output relation of the regulatory module, and the noise levels of binding and transcription satisfy certain matching relations. This parameter-free prediction is in good agreement with recent experiments on the Bicoid/Hunchback system in the early Drosophila embryo, and this system achieves ~90% of its theoretical maximum information transmission.

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