Influence of Hydrodynamic Interactions on Mechanical Unfolding of Proteins

Details Influence of Hydrodynamic Interactions on Mechanical Unfolding of Proteins Influence of Hydrodynamic Interactions on Mechanical Unfolding of Proteins

2007-06-08

arxiv.org/abs/0706.1102v1

Biology

Quantitative Biology

Biomolecules

to be published in Journal of Physics: Condensed Matter

Scientific paper

We incorporate hydrodynamic interactions in a structure-based model of
ubiquitin and demonstrate that the hydrodynamic coupling may reduce the peak
force when stretching the protein at constant speed, especially at larger
speeds. Hydrodynamic interactions are also shown to facilitate unfolding at
constant force and inhibit stretching by fluid flows.

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