Induction of high grade astrocytoma (HGA) by protons: Molecular mechanisms and RBE considerations

Details Induction of high grade astrocytoma (HGA) by protons: Molecular mechanisms and RBE considerations Induction of high grade astrocytoma (HGA) by protons: Molecular mechanisms and RBE considerations

Oct 1994

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1994adspr..14..267d&link_type=abstract

Advances in Space Research, Volume 14, Issue 10, p. 267-270.

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Scientific paper

Protons of a specific energy, 55 MeV, have been found to induce primary high grade astrocytomas (HGA) in the Rhesus monkey (Macaca mulatta). Brain tumors of this type were not induced by protons of other energies (32-2,300 MeV). Induction of HGA has been identified in human patients who have had radiation therapy to the head. We believe that the induction of HGA in the monkey is a consequence of dose distribution, not some unique ``toxic'' property of protons. Comparison of the human experience with the monkey data indicates the RBE for induction of brain tumors to be about one. It is unlikely that protons cause an unusual change in oncogenic expression, as compared to conventional electromagnetic radiation.

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