In-Vivo NMR of Hyperpolarized Helium-3 in the Human Lung at Very Low Magnetic Fields

Details In-Vivo NMR of Hyperpolarized Helium-3 in the Human Lung at Very Low Magnetic Fields In-Vivo NMR of Hyperpolarized Helium-3 in the Human Lung at Very Low Magnetic Fields

2002-07-31

arxiv.org/abs/physics/0207129v2

Physics

Medical Physics

In press: Journal of Magnetic Resonance. 22 pages, 8 figures, 30 references

Scientific paper

10.1016/S1090-7807(02)00198-2

We present NMR measurements of the diffusion of hyperpolarized helium-3 in the human lung performed at fields much lower than those of conventional MRI scanners. The measurements were made on standing subjects using homebuilt apparatus operating at 3 mT. Oxygen-limited transverse relaxation (T2 up to 15-35 s) could be measured in-vivo. Accurate global diffusion measurements have been performed in-vivo and in-vitro. 1D ADC mapping with high SNR demonstrates the real possibility of performing quality lung imaging at extremely low fields.

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