In vivo evidence of alternative loop geometries in DNA-protein complexes

Biology – Quantitative Biology – Biomolecules

Scientific paper

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

3 pages, 2 figures

Scientific paper

The in vivo free energy of looping double-stranded DNA by the lac repressor has a remarkable behavior whose origins are not fully understood. In addition to the intrinsic periodicity of the DNA double helix, the in vivo free energy has an oscillatory component of about half the helical period and oscillates asymmetrically with an amplitude significantly smaller than predicted by current theories. Here, we show that the in vivo behavior is accurately accounted for by the simultaneous presence of two distinct conformations of looped DNA. Our analysis reveals that these two conformations have different optimal free energies and phases and that they behave distinctly in the presence of key architectural proteins.

No associations

LandOfFree

Say what you really think

Search LandOfFree.com for scientists and scientific papers. Rate them and share your experience with other people.

Rating

In vivo evidence of alternative loop geometries in DNA-protein complexes does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with In vivo evidence of alternative loop geometries in DNA-protein complexes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and In vivo evidence of alternative loop geometries in DNA-protein complexes will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFWR-SCP-O-512923

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.