Biology – Quantitative Biology – Molecular Networks
Scientific paper
2006-05-19
Biology
Quantitative Biology
Molecular Networks
17 pages, 7 figures, accepted by Physica A
Scientific paper
10.1016/j.physa.2006.04.120
The observed structure of protein interaction networks is corrupted by many false positive/negative links. This observational incompleteness is abstracted as random link removal and a specific, experimentally motivated (spoke) link rearrangement. Their impact on the structural properties of gene-duplication-and-mutation network models is studied. For the degree distribution a curve collapse is found, showing no sensitive dependence on the link removal/rearrangement strengths and disallowing a quantitative extraction of model parameters. The spoke link rearrangement process moves other structural observables, like degree correlations, cluster coefficient and motif frequencies, closer to their counterparts extracted from the yeast data. This underlines the importance to take a precise modeling of the observational incompleteness into account when network structure models are to be quantitatively compared to data.
Glauche Ingmar
Greiner Martin
Kuhnt Mathias
No associations
LandOfFree
Impact of observational incompleteness on the structural properties of protein interaction networks does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with Impact of observational incompleteness on the structural properties of protein interaction networks, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Impact of observational incompleteness on the structural properties of protein interaction networks will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-243639