Identification of key genes for a complex disease: application of protein interactome and gene ontology analysis for obtaining secondary bone cancer specific targets

Details Identification of key genes for a complex disease: application of protein interactome and gene ontology analysis for obtaining secondary bone cancer specific targets Identification of key genes for a complex disease: application of protein interactome and gene ontology analysis for obtaining secondary bone cancer specific targets

2011-12-07

arxiv.org/abs/1112.1510v1

Biology

Quantitative Biology

Molecular Networks

39 Pages (with 13 pages of article and 26 pages of supplementary material). 4 Figures and 1 Table

Scientific paper

Secondary bone cancer (SBC) is a complex disease characterized by intricate molecular mechanisms. Metastasis of primary breast cancer and prostate cancer cells is the main cause of SBC. Towards our goal of identifying SBC-specific targets, we use a strategy based on protein interactome analysis and gene ontologies. First, we compiled a well-curated dataset of 83 SBC genes (SBCGs). Further, we constructed protein interactome comprising of proteins known to be involved in generic cancer mechanisms and also for those implicated in SBC mechanisms. We hypothesize that these protein interaction networks embody mechanisms and processes that are relevant in generic cancers and those specific to SBC, respectively. We, then, identified targets specific to SBC by combining key cancer-related genes, SBCGs and ontologically significant genes. These targets, apart from being ontologically relevant to SBC, are critical in the topology and dynamics of generic cancer mechanisms. Further, we refined the targets for SBC-specificity by filtering out the genes involved in primary bone cancer, any other type of cancer or any other known disease. Our composite rational strategy involving literature-mined experimental data, graph theoretical analysis and gene ontological studies predicts targets that are more specific and relevant for SBC.

Affiliated with

Also associated with

No associations

Rating

Identification of key genes for a complex disease: application of protein interactome and gene ontology analysis for obtaining secondary bone cancer specific targets does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Identification of key genes for a complex disease: application of protein interactome and gene ontology analysis for obtaining secondary bone cancer specific targets, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Identification of key genes for a complex disease: application of protein interactome and gene ontology analysis for obtaining secondary bone cancer specific targets will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-595254