How to design multi-target drugs: Target search options in cellular networks

Details How to design multi-target drugs: Target search options in cellular networks How to design multi-target drugs: Target search options in cellular networks

2007-03-04

arxiv.org/abs/q-bio/0703010v2

Expert Opinion on Drug Discovery (2007) 2:1-10

Biology

Quantitative Biology

Molecular Networks

12 pages, 3 figures, 1 table

Scientific paper

Despite improved rational drug design and a remarkable progress in genomic, proteomic and high-throughput screening methods, the number of novel, single-target drugs fell much behind expectations during the past decade. Multi-target drugs multiply the number of pharmacologically relevant target molecules by introducing a set of indirect, network-dependent effects. Parallel with this the low-affinity binding of multi-target drugs eases the constraints of druggability, and significantly increases the size of the druggable proteome. These effects tremendously expand the number of potential drug targets, and will introduce novel classes of multi-target drugs with smaller side effects and toxicity. Here we review the recent progress in this field, compare possible network attack strategies, and propose several methods to find target-sets for multi-target drugs.

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