How knots influence properties of proteins

Details How knots influence properties of proteins How knots influence properties of proteins

2008-10-02

arxiv.org/abs/0810.0415v1

PNAS 105 (2008) 19714

Biology

Quantitative Biology

Biomolecules

23 pages, 12 figures

Scientific paper

10.1073/pnas.0805468105

Molecular dynamics studies within a coarse-grained structure based model were used on two similar proteins belonging to the transcarbamylase family to probe the effects in the native structure of a knot. The first protein, N-acetylornithine transcarbamylase, contains no knot whereas human ormithine transcarbamylase contains a trefoil knot located deep within the sequence. In addition, we also analyzed a modified transferase with the knot removed by the appropriate change of a knot-making crossing of the protein chain. The studies of thermally- and mechanically-induced unfolding processes suggest a larger intrinsic stability of the protein with the knot.

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