How Big Is the Universe of Exons?

Details How Big Is the Universe of Exons? How Big Is the Universe of Exons?

Dec 1990

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1990sci...250.1377d&link_type=abstract

Science, Volume 250, Issue 4986, pp. 1377-1382

Physics

14

Scientific paper

If genes have been assembled from exon subunits, the frequency with which exons are reused leads to an estimate of the size of the underlying exon universe. An exon database was constructed from available protein sequences, and homologous exons were identified on the basis of amino acid identity; statistically significant matches were determined by Monte Carlo methods. It is estimated that only 1000 to 7000 exons were needed to construct all proteins.

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