Physics – Medical Physics
Scientific paper
2006-08-29
Physics
Medical Physics
12 pages, 8 figures
Scientific paper
Comparing both, the more conventional Gompertz tumor growth law (GL) and the ``Universal'' law (UL), recently proposed and applied to cancer,we have investigated the growth law's implications on various radiotherapy regimen. According to GL, the surviving tumor cell fraction could be reduced 'ad libidum', independently of the initial tumor mass,simply by increasing the number of treatments. On the contrary, if tumor growth dynamics would indeed follow the Universal scaling law, there is a lower limit of the survival fraction that cannot be reduced any further regardless of the total number of treatments. This finding can explain the so called ``tumor size effect'' and re-emphasizes the importance of early diagnosis as it implies that radiotherapy may be successful provided the tumor mass at treatment onset is rather small. Taken together with our previous works, implications of these findings include revisiting standard radiotherapy regimen and overall treatment protocols.
Castorina Paolo
Deisboeck Thomas S.
Gabriele Pietro
Guiot Caterina
No associations
LandOfFree
Growth Laws in Cancer: Implications for Radiotherapy does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with Growth Laws in Cancer: Implications for Radiotherapy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Growth Laws in Cancer: Implications for Radiotherapy will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-333627