Genetic Code: Aspects of Organization

Details Genetic Code: Aspects of Organization Genetic Code: Aspects of Organization

Jul 1966

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1966sci...153..420g&link_type=abstract

Science, Volume 153, Issue 3734, pp. 420-424

Physics

19

Scientific paper

The pattern of organization of the genetic code decreases to a minimum the phenotypic effects of mutation and of base-pairing errors in protein synthesis. Single base changes, especially transitions, usually cause either no amino acid change or the change to a chemically similar amino acid. The degree of degeneracy of the codons for an amino acid is correlated with their guanine-cytosine content. The code gives greater protection (by both degeneracy and guaninecytosine content of codons) to those amino acids that appear more frequently in proteins. Increased reliability of the protein-synthesis system afforded by this pattern of organization may have determined the fitness of the present code.

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