Gene-gene cooperativity in small networks

Details Gene-gene cooperativity in small networks Gene-gene cooperativity in small networks

2008-10-16

arxiv.org/abs/0810.2946v1

Biology

Quantitative Biology

Molecular Networks

22 pages, 10 figures

Scientific paper

We show how to construct a reduced description of interacting genes in noisy, small regulatory networks using coupled binary "spin" variables. Treating both the protein number and gene expression state variables stochastically and on equal footing we propose a mapping which connects the molecular level description of networks to the binary representation. We construct a phase diagram indicating when genes can be considered to be independent and when the coupling between them cannot be neglected leading to synchrony or correlations. We find that an appropriately mapped boolean description reproduces the probabilities of gene expression states of the full stochastic system very well and can be transfered to examples of self-regulatory systems with a larger number of gene copies.

Affiliated with

Also associated with

No associations

Rating

Gene-gene cooperativity in small networks does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Gene-gene cooperativity in small networks, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Gene-gene cooperativity in small networks will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-368234