Gene Expression Noise Facilitates Adaptation and Drug Resistance Independently of Mutation

Details Gene Expression Noise Facilitates Adaptation and Drug Resistance Independently of Mutation Gene Expression Noise Facilitates Adaptation and Drug Resistance Independently of Mutation

2011-10-28

arxiv.org/abs/1110.6467v2

Physical Review Letters, 107, 218101 (2011)

Physics

Biological Physics

5 pages, 3 figures

Scientific paper

We show that the effect of stress on the reproductive fitness of noisy cell populations can be modelled as first-passage time problem, and demonstrate that even relatively short-lived fluctuations in gene expression can ensure long-term survival of a drug-resistant population. We examine how this effect contributes to the development of drug-resistant cancer cells, and demonstrate that permanent immunity can arise independently of mutations.

Affiliated with

Also associated with

No associations

Rating

Gene Expression Noise Facilitates Adaptation and Drug Resistance Independently of Mutation does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Gene Expression Noise Facilitates Adaptation and Drug Resistance Independently of Mutation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Gene Expression Noise Facilitates Adaptation and Drug Resistance Independently of Mutation will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-199923