Gene circuit designs for noisy excitable dynamics

Details Gene circuit designs for noisy excitable dynamics Gene circuit designs for noisy excitable dynamics

2011-02-19

arxiv.org/abs/1102.4026v1

Mathematical Biosciences 231 (2011), pp. 90-97

Biology

Quantitative Biology

Molecular Networks

9 pages, 10 figures

Scientific paper

10.1016/j.mbs.2011.02.013

Certain cellular processes take the form of activity pulses that can be interpreted in terms of noise-driven excitable dynamics. Here we present an overview of different gene circuit architectures that exhibit excitable pulses of protein expression, when subject to molecular noise. Different types of excitable dynamics can occur depending on the bifurcation structure leading to the specific excitable phase-space topology. The bifurcation structure is not, however, linked to a particular circuit architecture. Thus a given gene circuit design can sustain different classes of excitable dynamics depending on the system parameters.

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