Functionalized nanopore-embedded electrodes for rapid DNA sequencing

Details Functionalized nanopore-embedded electrodes for rapid DNA sequencing Functionalized nanopore-embedded electrodes for rapid DNA sequencing

2007-08-29

arxiv.org/abs/0708.4011v1

J. Phys. Chem. C, 112 (10), 3456 -3459, 2008.

Physics

Biological Physics

12 pages, 5 figures

Scientific paper

10.1021/jp7115142

The determination of a patient's DNA sequence can, in principle, reveal an increased risk to fall ill with particular diseases [1,2] and help to design "personalized medicine" [3]. Moreover, statistical studies and comparison of genomes [4] of a large number of individuals are crucial for the analysis of mutations [5] and hereditary diseases, paving the way to preventive medicine [6]. DNA sequencing is, however, currently still a vastly time-consuming and very expensive task [4], consisting of pre-processing steps, the actual sequencing using the Sanger method, and post-processing in the form of data analysis [7]. Here we propose a new approach that relies on functionalized nanopore-embedded electrodes to achieve an unambiguous distinction of the four nucleic acid bases in the DNA sequencing process. This represents a significant improvement over previously studied designs [8,9] which cannot reliably distinguish all four bases of DNA. The transport properties of the setup investigated by us, employing state-of-the-art density functional theory together with the non-equilibrium Green's Function method, leads to current responses that differ by at least one order of magnitude for different bases and can thus provide a much more robust read-out of the base sequence. The implementation of our proposed setup could thus lead to a viable protocol for rapid DNA sequencing with significant consequences for the future of genome related research in particular and health care in general.

Affiliated with

Also associated with

No associations

Rating

Functionalized nanopore-embedded electrodes for rapid DNA sequencing does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Functionalized nanopore-embedded electrodes for rapid DNA sequencing, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Functionalized nanopore-embedded electrodes for rapid DNA sequencing will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-240792