Functional models for large-scale gene regulation networks: realism and fiction

Details Functional models for large-scale gene regulation networks: realism and fiction Functional models for large-scale gene regulation networks: realism and fiction

2009-02-12

arxiv.org/abs/0902.2083v1

Biology

Quantitative Biology

Molecular Networks

to appear on Mol. BioSyst. 2009

Scientific paper

High-throughput experiments are shedding light on the topology of large regulatory networks and at the same time their functional states, namely the states of activation of the nodes (for example transcript or protein levels) in different conditions, times, environments. We now possess a certain amount of information about these two levels of description, stored in libraries, databases and ontologies. A current challenge is to bridge the gap between topology and function, i.e. developing quantitative models aimed at characterizing the expression patterns of large sets of genes. However, approaches that work well for small networks become impossible to master at large scales, mainly because parameters proliferate. In this review we discuss the state of the art of large-scale functional network models, addressing the issue of what can be considered as realistic and what the main limitations may be. We also show some directions for future work, trying to set the goals that future models should try to achieve. Finally, we will emphasize the possible benefits in the understanding of biological mechanisms underlying complex multifactorial diseases, and in the development of novel strategies for the description and the treatment of such pathologies.

Affiliated with

Also associated with

No associations

Rating

Functional models for large-scale gene regulation networks: realism and fiction does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Functional models for large-scale gene regulation networks: realism and fiction, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Functional models for large-scale gene regulation networks: realism and fiction will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-556291