From features to expression: High-density oligonucleotide array analysis revisited

Details From features to expression: High-density oligonucleotide array analysis revisited From features to expression: High-density oligonucleotide array analysis revisited

2001-02-05

arxiv.org/abs/physics/0102010v2

Physics

Biological Physics

9 pages, 7 figures

Scientific paper

One of the most popular tools for large scale gene expression studies are high-density oligonucleotide (GeneChip(R)) arrays. These currently have 16-20 small probe cells (``features'') for evaluating the transcript abundance of each gene. In addition, each probe is accompanied by a mismatched probe designed as a control for non-specificity. An algorithm is presented to compute comparative expression levels from the intensities of the individual features, based on a statistical study of their distribution. Interestingly, MM probes need not be included in the analysis. We show that our algorithm improves significantly upon the current standard and leads to a substantially larger number of genes brought above the noise floor for further analysis.

Affiliated with

Also associated with

No associations

Rating

From features to expression: High-density oligonucleotide array analysis revisited does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with From features to expression: High-density oligonucleotide array analysis revisited, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and From features to expression: High-density oligonucleotide array analysis revisited will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-492489