Flux distribution in metabolic networks close to optimal biomass production

Details Flux distribution in metabolic networks close to optimal biomass production Flux distribution in metabolic networks close to optimal biomass production

2008-04-07

arxiv.org/abs/0804.1080v2

Phys. Rev. E 78, 035101 (2008).

Biology

Quantitative Biology

Molecular Networks

(4 pages,2 figures)

Scientific paper

10.1103/PhysRevE.78.035101

We study a statistical model describing the steady state distribution of the fluxes in a metabolic network. The resulting model on continuous variables can be solved by the cavity method. In particular analytical tractability is possible solving the cavity equation over an ensemble of networks with the same degree distribution of the real metabolic network. The flux distribution that optimizes production of biomass has a fat tail with a power-law exponent independent on the structural properties of the underling network. These results are in complete agreement with the Flux-Balance-Analysis outcome of the same system and in qualitative agreement with the experimental results.

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