Fluctuations of Complex Networks: Electrical Properties of Single Protein Nanodevices

Details Fluctuations of Complex Networks: Electrical Properties of Single Protein Nanodevices Fluctuations of Complex Networks: Electrical Properties of Single Protein Nanodevices

2004-06-08

arxiv.org/abs/q-bio/0406018v1

Biology

Quantitative Biology

Molecular Networks

16 Pages and 10 Figures published in SPIE Proceedings of the II International Symposium on Fluctuation and Noise, Maspalomas,G

Scientific paper

10.1117/12.547636

We present for the first time a complex network approach to the study of the electrical properties of single protein devices. In particular, we consider an electronic nanobiosensor based on a G-protein coupled receptor. By adopting a coarse grain description, the protein is modeled as a complex network of elementary impedances. The positions of the alpha-carbon atoms of each amino acid are taken as the nodes of the network. The amino acids are assumed to interact electrically among them. Consequently, a link is drawn between any pair of nodes neighboring in space within a given distance and an elementary impedance is associated with each link. The value of this impedance can be related to the physical and chemical properties of the amino acid pair and to their relative distance. Accordingly, the conformational changes of the receptor induced by the capture of the ligand, are translated into a variation of its electrical properties. Stochastic fluctuations in the value of the elementary impedances of the network, which mimic different physical effects, have also been considered. Preliminary results concerning the impedance spectrum of the network and its fluctuations are presented and discussed for different values of the model parameters.

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